生物技术公司PRELIS生物制剂宣布关闭一笔1450万美元的B系列融资，并创建一个新颖的抗体发现平台。
该公司的平台有效地是一种功能性的免疫系统，能够重现人类细胞之间的相互作用和免疫反应，使其非常适合进行疾病治疗R＆D。为了支持这些生物打印组织的持续发展，该公司还获得了新投资者的大力支持，据说他们对其潜力“非常兴奋”。
“The ‘EXIS’ platform offers unprecedented in-vitro access to a functional human immune system,” said Dr. Melanie P. Matheu, CEO of Prellis Biologics. “We’ve built a platform that enables promising science to be rapidly advanced into new patient therapies. We’re thrilled to continue expanding upon the exciting potential of this technology, thanks to the support of our investors and collaboration partners.”
Multiphoton Holographic technology
Based in San Francisco, Prellis Biologics specializes in the bioprinting of vascularized channels that serve as a basis for creating functional human tissues. Primarily, the company is able to achieve this thanks to its Multiphoton Holographic technology, an approach that’s similar to conventional vat polymerization, in which lasers are used to cure materials infused with live cells at a high speed and resolution.
过去，Prellis Biologics试图通过将其整合到CELLINK’s Holograph-X生物生产商。当时，据说所得的系统能够更有效地提供营养，从而更好地支持其生长到组织中，从而“赋予客户在3D生物构成人体器官领域的研究中促进其研究。”
Prellis Biologics本身还针对生物打印的类器官，着手产生人类肾脏vascular system inside of 12 hours in 2018, as a means of overcoming the cell deterioration hindering existing research, and it raised $8.7 million a year later, to further its experiments into the生物打印细胞的移植into a living animal model.
An ‘Externalized Immune System’
Using its proprietary 3D bioprinting technology, Prellis Biologics now appears to have shifted its focus away from attempting to create vascularized scaffolds, setting out to engineer more complex lymph node organoids instead, and following extensive research in this area, the firm has unveiled a breakthrough with its Externalized Immune System or ‘EXIS.’
Believed to be the first of its kind, Prellis Biologics’ EXIS is said to be capable of achieving interactions such as B cell class-switching and somatic hypermutation that are key to developing antibodies. The platform is also able to break cells’ natural failsafes, which often prevent auto-antibody development, thus it could now expedite the R&D of therapies for illnesses like cancer or autoimmune disease.
Already, Prellis Biologics says it has used EXIS to target antigens in various formats to produce human antibodies with high affinities, sequence diversity and potency, within a period of just 3 weeks. As a result, the firm believes that its platform has the potential to “significantly reduce the discovery and lead identification time” of existing in-vivo or in-vitro drug screening and vaccine testing methods.
To fund the ongoing development of its organoids, the company has also gained fresh investment, taking its total to $29.5 million, in a round led byCelesta Capitaland backed byKhosla Ventures。作为融资协议的一部分，Celesta Capital的Michael Marks和Ex-Berkeley Lights首席运营官Shaun Holt已同意加入Prellis Biologics董事会，并借用其专业知识来指导其未来的增长。
“如今，药物抗体发现需要很长时间，由于对动物的依赖而造成高昂的成本，并且抗体一旦达到人类试验，抗体就很少能执行。”“既然初步交易有助于证明其巨大的潜力，我们已经准备好支持EXIS平台的营销。”
3D bioprinting’s therapeutic potential
As the cellular viability of 3D printed tissues continues to advance, so do their potential applications as a means of testing the efficacy of novel drugs, therapeutics and even vaccines. Since last year, for instance,HK inno.N一直在与T&R Biofab到3D bioprint tissue test models用于评估新的自身免疫和皮肤疾病疗法。
Scientists at the中国科学院andUniversity of Science and Technology of China，甚至设法使用生物打印来发展‘curing’ untreatable spinal cord injuries。Leveraging a novel bio-ink, the Chinese team created neural stem cell-loaded tissues in July 2021, capable of carrying instructions via impulses from the brain, similar to those seen in living organisms.
最近，再生医学专家CTIBIOTECH是否利用其3D生物打印技术来生产独特的colon cancer treatment platform。Developed alongside theMedical University of Plovdivand UMHAT-Eurohospital, the tissues are designed to yield reproducible human colon cancer disease models for chemotherapeutic screening applications.
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Featured image shows a high-resolution image of Prellis Biologics’ 3D bioprinted Externalized Immune System. Image via Prellis Biologics.
