Medical & Dental

Bladder grown from 3D bioprinted tissue continues to function after 14 years

After more than a decade, a 3D bioprinted bladder, created by Dr. Anthony Atala at波士顿儿童医院, is sustaining the live of a patient. The 3D bioprinted organ was made to replace patient Luke Massella’s defective bladder in 2004. Since then, Massella has not required any further surgery.

回忆移植到BBC News, Massella stated “It was pretty much like getting a bladder transplant, but from my own cells, so you don’t have to deal with rejection. […] I was able to live a normal life after”

卢克·马塞拉(Luke Massella)于2001年与他的母亲和叔叔一起经过无数次手术。通过BBC新闻照片。
卢克·马塞拉(Luke Massella)于2001年与他的母亲和叔叔一起经过无数次手术。通过BBC新闻照片。

3D打印新膀胱

马塞拉(Massella)出生于脊柱裂,这在他的脊椎上留下了差距,并导致他在年轻时接受了几次手术。不幸的是,有缺陷的膀胱导致他的肾脏失败,使他有可能在余生中透析。值得庆幸的是,Atala博士提出了另一种解决方案。

膀胱是使用Massella的膀胱组织和改性喷墨打印机制成的,大概用于建造一种脚手架/host for the cells. Incubated in lab condition, the new bladder was grown in 2 months, and then successfully transplanted into the patient.

Massella is 1 of 10 people with a bioprinted bladder grown from his own cells. According to Dr. Atala, flat structures like skin are easiest to print, whereas tubular structures like blood vessels and hollow non-tubular organs like bladders are more complex. Solid organs like,肺部和肾脏是最难生物构图的,因为它们的细胞含量更高,尽管一些研究人员在该领域取得了很小的成功。

投资生物打印器官

The potential of 3D bioprinted organs has led further research by many organizations around the world. Recently, a team at印第安纳大学医学院(IUSM) were awarded $9 million to further他们的3D生物打印研究,用于开发可移植器官。领先的3D打印机制造商3D Systems已与联合治疗公司为了...的目的3D打印肺组织, 和Biolife4d研究人员在杨树和妇女医院(BWH)成功3D生物打印管结构which imitate the human body’s vessels.

BWH的3D印刷组织的生物相容性。通过预先材料照片。
来自Brigham和妇女医院(BWH)的管状3D印刷管道样品与波士顿儿童医院的工作无关。通过预先材料图像。

For more 3D bioprinting partnership updates subscribe to the3D打印行业newsletter, following us onFacebookand liking us on推特

Seeking new professional opportunities? Search and post3D打印作业now.

特色图片显示波士顿儿童医院。通过波士顿商业杂志的照片。