Medical & Dental

Idipazresearchers work with MIT on 3D printed cornea replacements

西班牙马德里的La Paz(Idipaz)的RespocitionunBioMédicadel Institutodevession1iónbiomédica研究所正在努力实现未来5年内3D印刷人类角膜的目标。

Contributing to a global shortage of donations, the synthetic eye tissues could be used to treat, and in some cases reverse, the onset of blindness caused by common eye diseases.

A project of notable significance, the research is backed by the IDEA² Global Linq initiative from the Massachusetts Institute of Technology (MIT).

马德里拉巴斯大学医院。丹尼尔·冈萨雷斯·查纳(Daniel Gonzalez Chana)
马德里拉巴斯大学医院。丹尼尔·冈萨雷斯·查纳(Daniel Gonzalez Chana)

Curing a leading cause of vision loss

Research into corneal stroma fabrication is lead byLa Paz大学医院的细胞工程小组的MaríaPazde Miguel。

Joining her on the corneal project is an interdisciplinary group of researchers across Spain’s leading medical institutions.

Included in the group isFrancisco Arnalich-Montiel,角膜疾病(角膜移植的最常见原因),居住在Hospital Universitario Ramón y Cajal.

Maria P De Miguel (center) is joined by Francisco Arnalich-Montiel, Manuel Nistal, Javier Regadera, Pilar Gonzalez-Peramato, Diana Martin, Adrian Moratilla, Verónica Aparicio, Anisia Martínez, Victor Paleo, and Andrea Santos in corneal stroma 3D fabrication. Photo via IdiPAZ
Maria P De Miguel (center) is joined by Francisco Arnalich-Montiel, Manuel Nistal, Javier Regadera, Pilar Gonzalez-Peramato, Diana Martin, Adrian Moratilla, Verónica Aparicio, Anisia Martínez, Victor Paleo, and Andrea Santos in corneal stroma 3D fabrication. Photo via IdiPAZ

Not “a culture of corneas”

As part of the IDEA² Global initiative, IdiPAZ researchers receive mentoring and expert connections from specialists at MIT.de Miguel et al.’s involvement in the生物医学创新项目was determined by the西班牙(FIPSE)的创新与预期健康基金会。

在西班牙出版电台和电视服务RTVE上发表讲话FIPSE代表规定“这是一种制造业,而不是角膜文化”,将技术与other 3D bioprinting research试图使用材料作为对单元的支持。

In order to achieve their goal the researchers propose a direct 3D printing method using native, autologous, stem cells to synthesize层的胶原蛋白for transplant. The technique will likely require the development of高分辨率3D生物打印过程,that layers tissue cell by cell.

A 5 year ambition

在5年的时间范围内,IDIPAZ团队计划在一周内生产特定于患者的角膜。虽然雄心勃勃,但以前的研究例如,匹兹堡大学健康科学学校的小鼠角膜的成功干细胞治疗,indicates that the project is entirely possible.

If successful the treatments could benefit the lives of around 10 million people with eye disease worldwide.

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Featured image: diagram of the human eye via Wikimedia Commons contributor Firkin