内部人士和分析师预测3D打印趋势to watch in our latest series of articles focused on the future of 3D printing.
愈合形状这是一家总部位于法国里昂的再生医学初创公司，预计将筹集680万美元的A系列资金，以使用活着的患者细胞开发3D生物打印的乳腺植入物。
The firm is supported by脉搏SAS是一家技术转移加速公司，自2020年1月推出以来，已从法国获得了超过一百万美元的公共资金和补贴。
愈合形状’s mission is to provide patient-specific 3D bioprinted breast implants for women who have undergone a mastectomy procedure after breast cancer. These implants can be printed in virtually any shape and size, and help reconstruct both the breast volume and the nipple-areolar complex without the risk of implant rejection.
“A woman will recover her own breast within six to nine months, with no trace of the bioprosthesis,” says Sophie Brac de la Perrière, CEO of Healshape. “This will help women accept their image and be happy with their bodies again.”
Over two million a year
根据世界卫生组织，全球超过200万妇女每年被诊断出患有乳腺癌。它是世界上最普遍的癌症，年龄近70万人死亡。
大约40％的被诊断患有这种疾病的人最终必须进行乳房切除术，该手术涉及部分或完全去除受影响的乳腺组织。但是，通过现代治疗，生存率大于90％，这意味着越来越多的女性正在寻求乳房重建治疗以取代损失的组织。
其中许多其乳房重建手术lve using either an artificial implant or soft tissue matrices from other humans and animals. Unfortunately, implants from these sources can result in too much variability for treatments to be considered reliable and there’s always the risk of an immune response, which can slow down the healing process.
Healshape的组织工程方法旨在通过将3D生物打印技术与从患者本身获取的活细胞培养物相结合来解决这些问题。
生物打印可吸收乳房植入物
The company’s bioprosthesis technology relies on a resorbable hydrogel that can be 3D bioprinted into any freeform shape. Once implanted in the patient, a fat transfer of the patient’s own body cells helps colonize the breast implant and develop it into natural breast tissue, all while the hydrogel is gradually resorbed and replaced.
Healthape的技术是由大量生物打印研究的结果3d.FAB platform由CNRS高级研究员Christophe Marquette领导Chimie et biochimieMoléculairesetsupramoléculaires（ICBMS），与实验室创作, a tissue engineering company founded by Amélie Thépot and Morgan Dos Santos. Healshape’s bioink technology is now patent-protected.
Marquette adds, “Initially, the technology was developed to print skin substitutes. For the Healshape project, it was necessary to adapt the process to printing volumes, and ensure subsequent consolidation of the biological ink to make it compatible with implantation in the body.”
Healthape的3D生物打印技术目前处于临床前阶段，预计未来两年将开始进行临床试验。
Just recently, Korea-based biotech startupplcoskin宣布它将领导一项致力于开发的国际联合研究项目new type of 3D printed breast implant。和...一起Yonsei University和LipocoatPlcoskin是一家位于荷兰的医疗设备涂料公司，在未来三年内将获得约2B赢（170万美元）。
Elsewhere, 3D printer manufacturer3D系统recently announced a co-development agreement with填料，一家再生医学公司，开发3D生物打印软组织结构用于乳房重建治疗。软组织结构与乳房植入物结合起来，将用于为下乳房提供支撑并扩展植入物口袋，从而增加植入物的整体覆盖范围。就像愈合形状一样，最终的目的是提高癌症幸存者乳房重建手术的成功率。
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Featured image shows Healshape scientists 3D bioprinting a custom breast implant. Photo via Healshape.
