Research

Researchers develop 3D printable wound dressings based on fruit

Researchers from theAristotle University of Thessaloniki(Auth),希腊,已经开发了具有伤口治疗功能的3D可打印直接和间接贴片。

在杂志上发表的文章中Pharmaceutics,,,,3D可打印油墨基于pectin, a naturally occurring substance found in berries, apples, and other fruit, which form free‐standing transparent films designed to treat shallow wounds and ulcers.

研究指出:“传统敷料(如棉绷带或纱布)吸收了伤口所含的水分,导致伤口表面脱水,随后降低了愈合率。”

“通过3D生物打印开发了在与水性介质接触后分解的独立透明薄膜,其中通过掺入颗粒的掺入有效地增强了制造敷料的抗菌和伤口处理活性。”

3D打印的伤口穿衣

根据Auth团队的说法,经常使用由聚合物制成的替代敷料,因为它提供了最佳的伤口处理条件。这是由于它能够维持伤口的水分,从而可以减轻患者的疼痛。此外,如果在某些时间范围内不改变,传统的敷料可能会变得有毒。

Thus, wound‐dressing systems were developed that could provide an adequate moisture environment under air and water-tight trauma, otherwise known as occlusive conditions. This dressing also uses natural, non‐toxic bioinks including materials such as apple pectin,manuka蜂蜜和蜂胶提取物是一种由蜜蜂制成的树脂样材料,以避免感染和污染。

这与皮肤成纤维细胞混合,这些细胞负责产生结缔组织。从这些成分中,使用Cellink可墨3D bioprinter. This led to an assessment of the patches on shallow wounds on itscytocompatibility, antimicrobial activity and in vitro wound-healing properties. The researchers observed that the antimicrobial and wound‐healing properties of the fabricated films were enhanced by the addition of propolis.

斑块(a)的理论维度,干燥后3D打印斑块的实验尺寸及其差异(c),因为它是通过方程计算的。通过塞萨洛尼基亚里士多德大学的照片。
Theoretical dimensions of the patches (a), experimental dimensions of the 3D printed
干燥后的斑块(b)及其差异(c),因为它是通过方程计算的。通过塞萨洛尼基亚里士多德大学的照片。

通过增材制造愈合雷电竞充值

经过各种溶液的实验,研究得出结论,“ 3D打印是一个重要的平台,可用于以受控方式以复杂几何形状的膜和斑块的生产。与传统的贴片生产(如溶剂播种方法)相比,这一事实使使用该技术有利。”

Previously, 3D bioprinting methods were leveraged to create a手持式3D生物生产工具能够打印皮肤细胞治疗对烧伤受害者的深厚伤口。该系统沉积表皮和皮肤细胞,以及生物中性聚合物和蛋白质的混合物,均匀地分布细胞层。

3D打印果胶膜的光学显微镜图像:(a)0%,(b)2.5%,5%,(c)10%,(d)20%和(e,f)30%w/w ccp。图片通过塞萨洛尼基亚里士多德大学。
3D打印果胶膜的光学显微镜图像:(a)0%,(b)2.5%,5%,(c)10%,(d)20%和(e,f)30%w/w cyclodextrin/propolis提取纳入复合物。图片通过塞萨洛尼基亚里士多德大学。

基于果胶的生物活性斑块的开发,用于使用3D生物包裹技术治疗溃疡和伤口透明由Eleftherios G. Andriotis,Georgios K. Eleftheriadis,Christina Karavasil和Dimitrios G. Fatouros合着。

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特色图像显示护士绷带受伤。通过Freepik的照片。