Upnano, a manufacturer of two photon polymerization (2PP) 3D printers, has launched its new纳米生物3D生物打印系统。
根据公司的旗舰NanoOne 3D printer, the NanoOne Bio is capable of printing 3D tissue structures with living cells from the meso- to the nanoscales. The company has also partnered with biomaterial developerXpect INX, aGhent University纺纱，创建一个基于水凝胶的生物键，供新系统使用。据报道，X Hydrobio INX U200是唯一使用户可以将活细胞直接从培养板中嵌入其中的树脂。
“ Upnano在开发3D打印设备和XPECT INX方面的合并能力在设计创新的3D Biopinting材料方面很好地凝胶在一起，” Upnano技术主管兼联合创始人Peter Gruber说。“我们共同开发了X Hydrobio INX U200，这是一种高度生物相容性的水凝胶，与此同时，我们提供了2份3D打印设备，该设备提供了市场上最大的印刷尺寸。”
The need for 3D cell cultures
Flat, 2D cell scaffolds have been the standard in biomedical research for a number of years now. However, according to UpNano, there is evidence to suggest that these 2D models do not accurately represent the 3D cellular interactions we find in living systems. As such, drug development based on 2D culture testing can often be misguided, resulting in millions in wasted R&D costs.
To date, the printing of highly-precise 3D scaffolds with embedded living cells has been held back by limitations in both materials and 3D bioprinting systems. The joint development of the NanoOne Bio and the X Hydrobio INX U200 resin looks to change this.
What does it mean for 3D bioprinting?
Xpemp的新生物互联是一种水溶性水凝胶，使用户能够直接从培养皿中整合活的2D细胞培养物。一旦嵌入生物互联，就可以将细胞直接馈入纳米生物，并在其中印刷在复杂的3D支架中。由于系统使用这样的高功率激光器，因此结构的打印既精确又快速，这意味着用户将能够轻松地制造厘米大型构造。
“The gelatin-based X Hydrobio INX U200 has been specifically developed for the encapsulation of multiple cell types, thereby allowing the generation of complex 3D microtissues,” explains Jasper Van Hoorick, project lead at Xpect INX. “The hydrogel mimics the natural cellular environment and is biodegradable, thereby allowing the cells to gradually substitute the material with newly formed tissue.”
With the launch of the NanoOne Bio, UpNano expects customers in both academia and industry. Cell structures resembling real biological tissues can now be 3D printed, enabling natural interactions between cells and environmental stimuli. Pharmaceutical firms and research institutions alike will be granted the power to design cell models more closely aligned with real human body conditions, making drug development and other biomedical research safer and all the more reliable.
由于生物打印的利基生态性质，该领域的许多技术发展仍然直接来自研究机构。就在上个月，一个来自巴斯大学和University of Bristol开发了一个新3D bioprinting technique that leverages acoustic energy. The sonolithography process uses computer-controlled ultrasound waves to precisely deposit biological particles and droplets into predetermined patterns on a substrate.
Elsewhere, at theKing Abdullah University of Science and Technology，科学家最近开发了一种新的3D打印方法hydrogel scaffolds based on ultrashort peptides. These short chains of amino acids, the building blocks of proteins, were used to form the basis of a newly-developed, cell-infused 3D printing bioink.
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特色图像显示了UPNANO纳米生物及其孵化室。通过Upnano的照片。
