Researchers fromRutgers University，新泽西州已经创建了生物启发的可编程微针，可使用投影微型造影术（PµSL）增强组织粘附。
Influenced by themicrohooks of parasites, barbed stingers of honeybees, and quills of porcupines,4D printed backward-facing barbs were fabricated and designed to deform horizontally to be minimally invasive upon tissue contact.霍恩·李, the senior author of the study published inAdvanced Functional Materials，解释：
“我们认为，我们的4D印刷微针阵列将允许使用微创，无疼痛和易于使用的微针，以提供药物，愈合伤口，生物传感和其他软组织应用。”
Bioinspired 4D printed needles
According to the researchers, hypodermic needles are prone to cause pain, scarring, and infection. As they are widely used in hospitals and labs for the extraction of blood and injection of drugs, these risks are rather common.微针have been looked at as a solution as they are short, thin, minimally invasive, and negate pain and the risk of infection.
Nonetheless, regarding drug delivery, microneedles do not exhibit strong adhesion to tissues. The study states, “Typical micromanufacturing techniques for microneedle fabrication yield a smooth and plain side profile, which inevitably results in weak tissue adhesion. Some living creatures in nature have developed interesting solutions to achieve strong tissue adhesion in the microscopic length-scale.”
罗格斯队观察到，蜜蜂的刺刺显示出70倍强的粘附力而不是针灸针。此外，与其巴布莱斯对应物相比，北美豪猪的天然羽化块具有微观向后可部署的倒钩。这些生物以及寄生虫的微钩被用来形成具有弯曲结构的4D印刷微针。
将运动添加到微针中
4D printing refers to 3D printing object which has programmable movement orshapeshiftingqualities. The transformable element of these barbed microneedles arise when they are immersed in ethanol for rinsing after thePµSL过程。这uncured monomers in the bottom portion of the barbs diffuse out leaving behind loose spaces, causing them to face the opposite direction after insertion.
Using chicken muscle tissue as a soft tissue model, the researchers achieved 18 times stronger tissue adhesion with these microneedles when compared to barbless needles. “We demonstrated control of thickness and bending curvature of the barbs by controlling light exposure time and material composition of the precursor solution,” the study concludes.
“4D Printing of a Bioinspired Microneedle Array with Backward‐Facing Barbs for Enhanced Tissue Adhesion透明由Daehoon Han合着，Riddish S. Morde，Stefano Mariani，Antonino A. La Mattina，Emanuele Vignali, Chen Yang, Giuseppe Barillaro, and Howon Lee.
认为这是屡获殊荣的研究？提名2020 3D Printing Industry Awards现在打开。
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Featured image shows 4D printed microneedles featuring backward-facing barbs that interlock with tissue when inserted, enhancing adhesion. Photo via Rutgers University.
