Germany-based亚太大学’sDigital Additive Production作为生物结构项目的一部分，设施（DAP）正在研究晶格结构的新锌 - 磁合金组合。DAP说激光束粉末床融合（PBF-LB）是唯一能够生产这些结构的方法。
Current bone defect treatments, like titanium implants and autologous bone grafts, have limitations in treating critical-size bone defects. This weakens surrounding bone tissue, not making them ideal for large defects. To tackle these drawbacks, the BioStruct consortium is working on a bioresorbable implant concept allowing patient-friendly bone healing. The challenge is to choose suitable materials and geometries for the body in addition to PBF-LB processing. Zinc and magnesium alloys have shown “promising” in the development of resorbable bone implants, says DAP.
Laser Beam Powder Bed Fusion – a new hope for patient-specific implants?
Laser Beam Powder Bed Fusion opens new design options for implants to meet patient-specific needs, such as mechanical stress and corrosion behavior at the application site. An algorithmic lattice structure design approach is used, in which the geometry and arrangement of individual struts or lattice cells are created parametrically according to the specified requirements. The produced lattice structure is tailored to the location of the bone defect and prepared for production with PBF-LB.
The scientists accomplished grain refinement and targeted microstructure adjustment in their research by adding small quantities of magnesium to zinc. This ZnMg alloy was used to effectively and reproducibly manufacture the first demonstrator as a lattice-structured jawbone implant. The lattice structure used in the demonstrator has a strut diameter of 200 μm.
The BioStruct project’s findings will be further expanded in the reACT alliance. Ready-to-use demonstrator implants will be created based on the knowledge acquired from the production and biocompatibility of the ZnMg demonstrator implants. Additionally, the design process will also be optimized and automated.
DAP椅子的成员正在创建一个材料和后处理的特定数据库，以及一个特定于应用程序的数据库，以自动将患者和与生产相关的需求整合到设计过程中。React Alliance的子项目是通过新颖的设计和材料概念以及设计助手的探索的原型实现来完成的。该联盟的总体目标是生产可满足患者特定需求并允许绅士治疗的定制的可生物吸收植入物。
通过添加剂制造在骨植入物中的进步雷电竞充值
Engineers from theDelft University of Technology利用基于挤出的3D打印来产生临时bone implants用多孔铁。这些由多孔铁制成的可生物降解的植入物在短期内具有巨大的潜力，因为它们会随着新骨形成的位置而分解。通过被人体吸收，临时植入物可以帮助减轻长时间炎症的风险，这通常是永久金属骨植入物（例如由钛制成的植物）的问题。Amir A. Zadpoor，首席作者研究，说：“与其他可生物降解的金属或骨植入物的聚合物相比，铁具有很高的机械强度，可以设计和制造多孔结构，以治疗临界骨缺损。”
University of New South Wales(UNSW) researchers created a novel technique for 3D printing模拟骨结构comprising living cells, with potential applications in bone tissue engineering, disease modeling, and drug screening. Associate Professor Kristopher Kilian says the method could facilitate in-situ reconstruction of cartilage and bone defects by extruding the ceramic-based ink directly into the affected region. Kilian worked with Dr. Iman Roohani of UNSW’s School of Chemistry on the discovery, which enabled the printing of cell-laden “bone” at room temperature for the first time.
什么does the3D打印的未来for the next ten years hold?
什么engineering challengeswill need to be tackled in the additive manufacturing sector in the coming decade?
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Featured image shows a Mandibular model made of PLA with a defect-fitting implant made of ZnMg additively manufactured based on RWTH DAP’s newly developed design and alloy concept. Image via RWTH Aachen University.
