3D Systems美国领先的添加剂制造公司已宣布了再雷电竞充值生组织计划（RPT）的计划。该战略计划旨在开发和商业化生物打印的人体组织，并以内部产品（例如虚拟手术计划（VSP）（VSP））和最近的收购（包括）在内的3D系统专业知识（包括$400M purchase of Volumetric Biotechnologies。
Since being appointed CEO, Dr. Jeffrey Graves has clearly defined his vision for 3D Systems to lead in the medical vertical. On an earnings call last year, Graves singled outmedical 3D printingfor “patient solutions” as an “increasingly exciting market” where 3D Systems is “a clear leader.” Graves continued with optimism when he unveiled the new tissue program, claiming that 3D Systems development of “patient-specific human tissues” will “dramatically alter how patient care is delivered.”
Potential to produce patient-specific regenerative breast tissue
再生组织程序借鉴了在固体器官开发中获得的经验和专业知识，以解决非器官应用。Martine Rothblatt博士在去年的生活本身会议上详细介绍了一项针对3D印刷器官的策略。3D Systems合作伙伴联合Therapeutics的首席执行官Rothblatt宣布了一个雄心勃勃的目标 -3D印刷肺在不到五年的时间内清理人类试验。
The first RPT product under development relates to patient-specific regenerative breast tissue (RBT™). Katie Weimer, vice president of regenerative medicine at 3D Systems, says RBT “sets us apart” from competitors. Weimer further sees the program as opening “tremendous opportunities in providing a unique solution to breast reconstruction surgeons and patients.”
Targeting breast tissue meets a growing demand. According to the世界卫生组织, the breast cancer five-year post-diagnosis survival rate has increased to over 90% in high-income countries. Consequently, the need for long-term patient-specific regenerative breast reconstruction is rising. In contrast, current options for tissue reconstruction after mastectomy often prove unsatisfactory, with complications and additional procedures frequently required following surgery.
3D Systems says that by using 3D modeling and 3D bioprinting technology alongside its Virtual Surgical Planning (VSP) system, it will be able to design and produce bio-integrative scaffolds that match the patient’s anatomy and physiology. Patients will be able to receive personalized regenerative soft tissue, improving long-term outcomes with an optimized patient experience.
3D Systems explains it has already conducted a good deal of research into producing patient-specific regenerative soft tissue, guiding its efforts and providing evidence that these claims are feasible in practice. The company states that over the past 12 months, multiple large animal studies have been conducted, which give a proof-of-concept regarding the bio-integrative scaffolds that enable body fat regeneration. These scaffolds are constructed from biocompatible materials and possess tunable material properties. The company has also demonstrated an ability to connect scaffolds directly to the human vasculature. In effect, this will allow for personalized breast-size human-tissue reconstructions.
韦默尔（Weimer）说：“添加剂技术的好处不仅限于这些应用，因此“这项工作将扩展到未来的应用中，例如乳房切除术，隆胸和面部植入物。”
Advanced healthcare at 3D Systems
A focus on advanced regenerative healthcare is familiar to 3D Systems. Their2021 acquisition总部位于宾夕法尼亚州的3D BioProinter开发人员Allevi在再生医学研究方向上标志着明显的一步。Allevi生产的3D生物印刷技术和生物学技术可以在全球380多种制药和医疗实验室中找到，并提供众多再生医学应用。当时，格雷夫斯（Graves）对“专业知识，能力和技术”提供了兴奋，这一收购构成了该公司四步增长计划的重要组成部分。
3D系统于2022年9月宣布formation of Systemic Bio。这种新的3D生物打印子公司利用Alevi及其开发的技术打印到灌注program。由全身性生物产生的血管化3D支架可以用来自不同器官的健康和患病的人类细胞播种。这提供了一种新颖的药物安全性和功效测试过程，这些细胞已经被证明能够准确模拟人类免疫反应。因此，系统性简历旨在通过作为药物发现工具作为药品药物发现工具营销这一开发项目，每年收入1亿美元。
再生医学的3D打印
The additive applications to regenerative medicine are not limited to producing bioprinted human tissue. Indeed, a variety of broad uses are being pursued by additive manufacturers within this industry.
以色列的再生医学专家胶结植物recently announced that its proprietary3D bioprinted breast implants已经成功地通过了动物测试阶段。这些植入物通过将重组人胶原蛋白（Rhcollagen）种植到基因设计的烟草植物上，提供胶原蛋白的替代品。利用这一过程，该公司已经开发了内部3D生物打印的乳房植入物，并正在寻求人类试验和最终推出市场。
此外，五家Fraunhofer研究机构的研究人员试图开发一种独特的方法来生产患者特定的手指关节植入物。这已经实现了combining AI and 3D printing将2D X射线图像变成3D指模型。此过程是“ FingerKit”项目的一部分，据说该项目有助于纠正任何手指定位问题。
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Featured image shows the 3D Systems Healthcare Technology Center. Photo by 3D Printing Industry.
