提名2022 3D印刷行业奖are now open. Who do you think should make the shortlists for this year’s show? Let us know by casting your vote now.
Welsh biotech firmsJellagenandCopner Biotechhave deployed a novel 3D bioprinting process to turn bio-inks made from jellyfish collagen into “world-first” functional soft tissue structures.
使用Jellagen's胶原蛋白类型0bio-ink和Copner Biotech的GRAPE S1 3D bioprinter，这对夫妇提出了一种从人造材料和活细胞创建功能组织的过程。尽管许多现有的生物打印方法依赖于哺乳动物细胞，而哺乳动物细胞可能会带来道德上的考虑因素，但该公司表示，他们可以提供一种参与组织工程研发的较少争议的方式。
Jellagen创始人Andrew Mearns Spragg教授说：“我们对该项目的数据输出感到高兴，这些数据输出清楚地证明了我们的0型生物材料在未来的Bio-Ink开发中进一步使用。”“我们很高兴看到如何进一步发展为医学组织工程应用和细胞培养研究市场解决方案。”
Copner Biotech’s GRAPE S1 system
Copner Biotech成立于2020年，专门研究3D细胞培养和其他相关技术的研发。最初，威尔士初创公司所拥有的所有概念都是“下一代3D打印技术”，它可能能够创建PETG脚手架。然而，这些支架需要播种数量少的脚手架，此后表现出优化细胞捕获和附着的能力。
This development saw the company presented with the Global Health and Pharma International Life Sciences Award for Innovation in July 2021. Copner Biotech is also said to have entered into “several high-value research projects,” with Welsh Government support, including most recently, its 3D bioprinting work with Jellagen.
As announced in October 2021, the aim ofJellagen and Copner Biotech’s partnershipis to optimize the performance of the GRAPE S1 extrusion 3D bioprinter. The system works by using microfluidic droplet deposition to create layers via sequential printhead movement, in a process that’s designed to yield a high level of print precision and control.
Rather than relying on traditional STL or G-code files, Copner Biotech’s next generation bioprinter uses graphical rectangular actual positional encoding or ‘GRAPE’ files. These are programmed to tackle troublesome data approximations, modeling anomalies and low accuracy levels, in a way that enables the production of repeatable cell-based structures.
葡萄S1的另一个好处是，它通过从开源微流体储层中收集的材料打印，使用户可以利用其选择的单元格组合。Copner Biotech预计该系统的开放式设置将很快“授权研究社区推动3D Bioprinting的界限”，并与Jellagen合作，现在已经开始意识到该技术的潜力。
A Welsh 3D bioprinting R&D initiative
According to Jellagen and Copner Biotech, many current bioprinting systems on the market are limited by “dated software protocols,” and rely on mammalian sources of biomimetic materials and living cells. Backed by Wales’ business R&D investor scheme,smartcymru, the firms’ project has seen them collaborate since last year, on developing an alternative from Jellagen’s next-generation biomaterial.
As this Collagen Type 0 bio-ink is harvested from Barrel Jellyfish in the Irish Sea, which are fast becoming pests off the coast of the UK, the firm has positioned its production as a way of maintaining biodiversity. In theory, as the material is sourced from the root of the evolutionary tree, Jellagen says Collagen Type 0 is safer, purer and more effective and versatile than mammalian counterparts.
两家公司使用胶原蛋白0作为生物墨水，说他们现在已经在Copner Biotech的葡萄S1上设法实现了3D印刷的直径非常细，直径不到100m的组织结构。结合先进的算法，据说该过程允许进行3D体系结构的精确建模，以便可以使它们模仿生活系统的有机微环境。
Moving forwards, the project participants believe their workflow could be of particular importance in bioscience R&D, within the creation of repeatable 3D cell culture models. Though not designed to 3D bioprint transplantable structures, Copner Biotech CEO Jordan Copner says the technology it has developed with Jellagen, has the potential to “transform lives through tissue engineering.”
3D生物打印领域的生物墨水
Cell-depositing hardware isn’t the only area of 3D bioprinting that continues to be the subject of intense research, and scientists have made a number of bio-ink R&D advances in recent years. Researchers at the IrishRCSI医学与健康科学大学提出了伤口治疗3D生物打印墨水that can be turned into regenerative tissue scaffolds, which mend skin without scarring.
This followed the development of a new基于丝绸的3D印刷生物墨水at Japan’sOsaka University据说可以使富含细胞的结构的生产具有改善的可打印性。在测试过程中，发现科学家的材料可最大程度地减少3D打印过程中放置在细胞上的内部应力，从而提高了其生存能力，并使它们能够保留复杂的生物模仿形状。
最近，一个团队Cornell Universityhave managed to develop a3D printable biohybrid compositethat can be used to create artificial skin, which replicates the behavior of its real-life counterpart. Soft and biocompatible, but also flexible enough to withstand continued distortion, it’s thought the material could one day be used to fabricate scaffolds from patients’ cells that heal wounds in-situ.
To stay up to date with the latest 3D printing news, don’t forget to subscribe to the3D打印行业通讯or follow us onTwitteror liking our page onFacebook。
当您在这里时，为什么不订阅我们Youtubechannel? featuring discussion, debriefs, video shorts and webinar replays.
您是否正在寻找添加剂制造业的工作？雷电竞充值访问3D打印作业for a selection of roles in the industry.
Featured image shows a 40X magnified image of a 3D bioprinted Collagen Type 0 structure. Photo via Copner Biotech.
