Research

Researchers develop 3D printed parts to fight infectious diseases

Scientists from theUniversity of Sheffieldhave integrated抗菌特性成为聚合物粉末,以创建能够抵抗传染病的3D印刷零件。

In a study published inScientific Reports, silver-based additives were combined withPA 12然后使用EOS Formiga P100SLS system to additively manufacture antimicrobial components that were not toxic to human cells.

Sheffield高级添加剂制造中心的Candice Majewski博士,这项研究的首席研究员说,雷电竞充值“管理有害细菌的传播,感染个案n and the increasing resistance to antibiotics is a global concern. Introducing antibacterial protection to products and devices at the point of manufacture could be an essential tool in this fight.”

Fights diseases with additive manufacturing

根据研究人员的说法,目前可以购买抗菌产品,由于希望改善健康的愿望,全球抗菌添加剂市场不断增长。可以在植入物,假肢,夹板以及临床环境(例如门,水槽,仪器和键盘)中看到它们。

选择包含抗菌添加剂的3D打印零件(即Biocote B65003)进入细菌溶液中,以测试其一天后减少细菌数量的能力。发现含有抗菌添加剂的部分对两个主要细菌组有效,革兰氏阳性(革兰氏阳性)(金黄色葡萄球菌)和革兰氏阴性(铜绿假单胞菌). This kind of bacteria is known to cause life-threatening diseases such as pneumonia, meningitis, sepsis, and MRSA.

“The engineering properties of the new composite are indistinguishable from those of the standard polyamide 12 base material,” the study continues. “The material is most effective in nutrient-poor hydrated environments and under these circumstances is able to reduce numbers of planktonic bacteria in its surroundings and numbers of biofilm bacteria attached to the surface.”

A selection of parts made from PA2200 (left) alongside the 1% B65003 composite material (right). Photo via the University of Sheffield.
A selection of parts made from PA2200 (left) alongside the 1% B65003 composite material (right). Photo via the University of Sheffield.

另一层保护

Following experimentation, the group has deduced that their material could be applicable to intermittently hydrated environments including kitchens, bathrooms and on hospital wards. It can also be seen as another level of protection to coated medical devices, which often are subject to strict cleaning, sterilization procedures, causing human errors.

“当前大多数3D印刷产品没有其他功能。在制造阶段添加抗菌特性将在我们对流程能力的利用方面提供逐步变化。” Majewski博士补充说。研究人员现在计划进行现场试验,以验证现实世界中的实验室结果。

Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts” is co-authored by Robert D. Turner, James R. Wingham, Thomas E. Paterson, Joanna Shepherd, and Candice Majewski.

(e)基本材料的X射线微断层扫描部分(PA2200),显示孔。(f)复合材料的X射线微断层扫描段,显示了磷酸银玻璃颗粒的均匀分布。通过谢菲尔德大学的图像。
(e) X-Ray microtomography section of base material (PA2200), showing pores. (f) X-Ray microtomography section of the composite showing even distribution of silver phosphate glass particles. Image via the University of Sheffield.

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特色图像显示了基本材料(PA2200)的X射线显微图片截面,显示了复合材料的毛孔和一个X射线显微图片截面,显示了磷酸银玻璃颗粒的均匀分布。通过谢菲尔德大学的图像。