韩国科学家正在努力通过3D生物打印改善癌症治疗。
ProfessorSun Ha Paek, Chairman in the Department of Neurosurgery atSeoul National University医院(SNUH), and Professor Dong-Woo Cho of thePohang University of Science and Technology(POSTECH) have 3D bioprinted glioblastoma-on-a-chip devices to understand the behavior of cancer cells.
胶质母细胞瘤，也称为多形胶质母细胞瘤（GBM），是在大脑或脊髓中发现的一种侵略性癌症。在一项发表的研究中Nature Biomedical Engineering,科学家详细介绍了如何从癌症患者中提取GBM细胞ex vivomodel can emulate the characteristics of GBM human tumors.佩克教授解释：
“[This] system confirms that cell-printing technology could be used to find a customized anticancer combination for each patient in the future treatment of brain cancer.”
3D bioprinting cancer cells
这项研究称，GBM是最常见的脑癌形式，占所有恶性原发性脑肿瘤的约50％，被认为是高度难治性（耐药性）。
A team of bioengineers, led by Professor Paek and Professor Cho sought to combat the ineffectiveness of such treat通过观察从化学疗法改善和恶化症状的患者中观察到分离的癌细胞。
由GBM和人血管细胞被依次打印以创建Concentric环结构on a chip which was also 3D printed from oxygen-permeable silicone. Using this chip the structural, biochemical and biophysical properties of the GBM tumors could be replicated.
口服化疗药物temozolomide was used to create a reaction in the cells similar to the clinical outcomes of chemotherapy. The research states that the“芯片上的胶质母细胞瘤再现了临床观察到的患者特异性耐药性，可用于化学放疗。
“The model can be used to determine drug combinations associated with superior tumor killing for glioblastoma patients resistant to standard first-line treatment.”
“A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy”由hee-gyeong yi，Young Hun Jeong，Yona Kim，Yeong Jin Choi，Hyo Eun Moon，Sung Hye Park，Kyung Shin Kang，Mihyeon Bae，Jinah Jang，Jinah Jang，Hyewon Youn，Sun Ha Paek和Dong-Woo Cho。
Similarly, Shalini Guleria, Masters student at the怀卡托大学，新西兰，是3D打印乳腺肿瘤细胞to identify the best treatment for cancer patients. Last year, Guleria created a prototype tumor model using FFF 3D printing and is following this design in the development of an ex vivo生物打印模型。
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特色图像显示了GBM患者的代表性大脑磁共振图像。通过SNUH/POSTECH图像。
